Thematic review series: The Immune System and Atherogenesis. Cytokine regulation of macrophage functions in atherogenesis
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چکیده
منابع مشابه
Thematic review series: The immune system and atherogenesis. Cytokine regulation of macrophage functions in atherogenesis.
This review will focus on the role of cytokines in the behavior of macrophages, a prominent cell type of atherosclerotic lesions. Once these macrophages have immigrated into the vessel wall, they propagate the development of atherosclerosis by modifying lipoproteins, accumulating intracellular lipids, remodeling the extracellular environment, and promoting local coagulation. The numerous cytoki...
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t is now widely recognized that the evolving atherosclerotic esion has nearly all of the characteristics of a chronic nflammatory disease, including the active participation of any arcs of immune function. That immune mechanisms lay an important, if not dominant, role once atherosclerosis as been initiated is attested to by scores of examples in hich manipulations of both adaptive and innate im...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2005
ISSN: 0022-2275
DOI: 10.1194/jlr.r500009-jlr200